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MANDATORY READING MATERIAL FOR THE IBCMT EXAMS
We have great news!
The new, twelfth edition, Textbook of Clinical Metal Toxicology is out and it is better than ever before.
Dr. VanDerSchaar has just finished the twelfth edition of the Textbook “Clinical Metal Toxicology” (600 pages A+) It is available right now. The cost is 100 Euro, postage excluded.
Many new items were added and chapters were revised and updated with the most recent data.
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The following books and articles are recommended or may be used for presentations, references etc.
The IBCMT Secretariat will inform you about availability
of this literature.
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Agata Calderone, Teresa Jover, * Toshihiro Mashiko, * Kyung-min Noh, Hidenobu Tanaka, Michael V. L. Bennett, and R. Suzanne Zukin. Late Calcium EDTA Rescues Hippocampal CA1 Neurons from Global Ischemia-Induced Death. Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461 The Journal of Neuroscience, November 3, 2004, 24(44):9903-9913; JNEUROSCI.1713-04.2004
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Klassen CD: Heavy metals and heavy metal antagonists. Goodman and Gilman's :The Pharmacological Basis of Therapeutics. 6th Ed.: 1627,1980
Klassen CD: Heavy metals and heavy metal antagonists. Goodman and Gilman's :The Pharmacological Basis of Therapeutics. 6th Ed.: 1634,1980
Klassen CD: Heavy metals and heavy metal antagonists, in Gilman AG, Goodman LS, Rall TW, Murad F (eds): The pharmacological Basis of Therapeutics, 7th ed. New York, Macmillan, pp. 1605,1985
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Keberle M: The biochemistry of desferrioxamine and its relation to iron metabolism. Ann NY Acad Sci 119:758, 1964
Lipschitz D, Dugard J, Simon M, et al: The site of action of desferrioxamine. Br J Haematol 20:396, 1971
Westlin W: Deferoxamine in the treatment of acute iron poisoning - Clinical experiences with 172 children. Clin Pediatr 5:531, 1966
Hruby K, and Donner A: 2,3-dimercapto-1-proponesulfonate in heavy metal poisoning. Medical Toxicol 2:317,1987
McGowan EL, Tillotson JA, Knudsen JJ, and Dumalo CR: Biological behavior and metabolic fate of the BAL analogues DMSA and DMPS. Proc West Pharmacol Soc 27:169, 1984
Graziano JH, Leong JK, and Friedheim E: 2,3 Dimercaptosuccinic acid: a new agent for the treatment of lead poisoning. J Pharm Exp Ther 206:697, 1978
Graziano JH: Role of 2,3 dimercaptosuccinic acid in the treatment of heavy metal poisoning. Med Toxicol 1:155, 1986
Kapoor SC, Wielopolski L, Graziano JH, and LoIocano NJ: Influence of 2,3-dimercaptosuccinic acid on gastrointestinal lead absorption and whole-body lead retention. Toxicol Appl Pharmacol 97:525, 1989
Maiorino RM, Bruce DC, and Aposhian HV: Determination and metabolism of dithiol chelating agents: VI. Isolation and identification of the mixed disulfides of meso-2,3-dimercaptosuccinic acid with L-cysteine in human urine. Toxicol Appl Pharmacol 97:338, 1989
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Stein HB, Patterson AC, Offer RC, et al: Adverse effects of d-penicilamine in rheumatoid arthritis. Ann Int Med 92:24, 1980
Walshe JM: Penicillamine, new oral therapy for Wilson's disease. Am J Med. 21:487, 1956
Calcium disodium edetate and disodium edetate. Drugs for human use; drug efficacy study implementation. Department of Health, Education, and Welfare. Food and Drug Administration. Federal Registrar 35 F.R. 437, 1970.
Cheraskin E, Wussow DG, McDonagh EW and Rudolph CJ: Effect of EDTA chelation and supportive multivitamin/trace mineral supplementation with and without physical activity on the heart rate. J InternAcadof Prev Medi 8(6):5, 1984.
Cohen SH, Gong JK and Fishler MC: Ethylene diamine tetraacetic acid (EDTA) treatment of internal radioactive contamination. Nucleonics (11)1: 56, 1953.
Darwish NM and Kratzer FH: Metabolism of ethylenediaminetetraacetic acid (EDTA) by chickens. J Nutr 86:187, 1965.
Donsbach KW: Chelation Therapy; Has the Plug Been Pulled on Our Biggest Killer? Huntington Beach, CA, International Institute of Health, 1981.
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Grier MT and Meyers DG: So much writing, so little science: A review of 37 years of literature on edetate sodium chelation therapy. Ann Pharmacother 27:1504, 1993
Halstead BW, Rozema T: The Scientific Basis of EDTA ChelationTherapy, Second Edition. Tryon, N.C. TRC Publishing, Box 1241, Tryon NC 28782
Harper JW and Gordon GF: Reprints of Medical Literature on Chelation Therapy. Los Angeles, American Academy of Medical Preventics, 1975.
Hausmann E: Changes in plasma phosphate concentration on infusion of calcium gluconate or Na2EDTA. Proc Soc Exp Biol Med 134:182, 1970.
Hay DR: Chelation therapy. N Z Med J 101(841):122, 1988.
Hay DR: Chelation therapy. N Z Med J 101(845):246, 1988.
HoIm LW: The use of calcium disodium salt of Versene in heavy-metal poisoning of livestock. Proc Am Vet Med Assoc (48): 33, 1954.
Jonas WB: Meta-analysis of EDTA chelation: Math that doesn’t matter. J Adv Med 7:109, 1994.
Jonas WB: Effectiveness of EDTA chelation therapy. Circulation 5:1352, 1995.
Koen A, McCann DS and Boyle AJ: Some in vivo effects of chelation. II. Animal experimentation. J Chron Dis 16:329, 1963.
Jones RJ: Chelation therapy (Letter). JAMA 250:672, 1983.
Konradi MG: Use of the disodium ethylene diamine tetraacetate for diagnosing latent forms of hypoparathyroidism. Prob Endokrinol (Russ.) (23)3: 46, 1977.
Kozlov VA and Novikova VM: Calcium ion-dependent immunosuppressive effect of ethylenediaminetetraacetic acid (EDTA). Zh Mikrobiol, Epidemiol Immunobiol (Russ.) (1): 69, 1978.
Leitner SA: Last chance to live. Wade Allen Publishing, Chesterfield, MO, 1980.
Luchi RJ, Helwig J Jr and Conn HL Jr: Quinidine txoicity and its treatment. An experimental study. Am Heart J 65:340, 1963.
Lelievre P and Betz EH: Effect of versene on oxygen consumption of tissues in vitro. C R Soc Biol 155:199, 1961.
Liberman UA, Barzel U, De Vries A and Ellis H: Myositis ossificans traumatica with unusual course. Effect of EDTA on calcium, phosphorus and mangenese excretion. Am J Med Sci 254:35, 1967.
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Magee HR: Chelation treatment of atherosclerosis. Med J Aust 142:514, 1985.
Maxwell GM, Elliot RB and Robertson E: The effect of Na3EDTA-induced hypocalcemia upon the general and coronary hemodynamics of the intact animal. Am Heart J 66:82, 1963.
Meltzer L, Kitchell J and Palmon F: The long term use, side effects, and toxicity of disodium ethylelenediaminetetraacetic acid (EDTA). Am J Med Sci (242): 11, 1961
McCoy JE, Carre IJ and Freeman M: A controlled trial of edathamil calcium disodium in acrodynia. Pediatrics 25:304, 1960.
McDonagh E: Circulation changes in extremities with chelation therapy. Paper presented at American Academy of Medical Preventics Fall Conference, Las Vegas, Nevada, November, 1982
McDonagh EW, Rudolph CJ and Cheraskin E: The homeostatic effect of EDTA with supportive multivitamin trace mineral supplementation upon high-density lipoproteins (HDL). J Osteopath Phys Surg Calif 8: #2, Spring 1982.
McDonagh EW, Rudolph CJ and Cheraskin E: The effect of intra-venous disodium ethylenediaminetetraacetic acid (EDTA) plus supportive multivitamin/trace mineral supplementation upon fasting serum calcium. Med Hypotheses 11:431, 1982.
McDonagh EW, Rudolph CJ and Cheraskin E: The glycohemoglobin (HbA1c) distribution in EDTA chelation eligible patients. J Orthomolecular Psych 12:72,1983.
McDonagh EW and Rudolph CJ: A collection of published papers showing the efficacy of EDTA chelation Therapy. Gladstone, MO, McDonagh Medical Center, 1991.
McDonagh EW: Chelation can cure: How to reverse heart disease, diabetes, stroke, high blood pressure or surgery. Kansas City, Platinum Pen Publications, 1983.
McDonagh EW, Rudolph CJ and Cheraskin E: The effect of intravenous disodium ethylene diamine tetraacetic acid (EDTA) upon blood cholesterol levels in a private practice environment. J Intern Acad of Prev Med 7:5, 1982.
McDonagh E.W, Rudolph CJ and Cheraskin E: The effect of EDTA chelation therapy with multivitamin/trace mineral supplementation upon reported fatigue. J of Orthomol Psy 13(4):1, 1984.
McDonagh EW ,Rudolph CJ, Cheraskin E and Wussow DG: The effect of EDTA chelation and supportive multivitamin/trace mineral supplementation with and without physical activity upon systolic blood pressure. J Orthomol Psy 13;1, 1984.
McDonagh EW,, Rudolph CJ and Cheraskin E: The psychotherapeutic potential of EDTA chelation. The J OrthomolPsy 14(3):214, 1985.
McDonagh EW, Rudolph CJ and Cheraskin E: The clinical changes in patients treated with EDTA chelation plus multivitamin/trace mineral supplementation. The J Orthomol Psy 14(1):61, 1985.
McDonagh EW, Rudolph CJ and Cheraskin E: An oculocerebrovasculometric analysis of the improvement in vascular stenosis following edta chelation therapy. J Holistic Med 4(1): 21, 1982
McDonagh EW, Rudolph CJ and Cheraskin E: The Influence of EDTA salts plus multivitamin-trace mineral therapy upon total serum cholesterol/high-density lipoprotein cholesterol. Med Hypotheses 9:643, 1982
McDonagh EW, Rudolph CJ, and Cheraskin E: The effect of EDTA chelation therapy plus multivitamin/trace mineral supplementation upon vascular dynamics: ankle/brachial doppler systolic blood pressure ratio. J Holistic Med 7(1):16, 1985.
McDonagh EW, Rudolph CJ ,Cheraskin E: The effect of EDTA chelation therapy plus supportive multivitamin-trace mineral supplementation upon renal function: A study in serum creatinine. J Holistic Medicine 4:146, 1982.
McDonagh EW, Rudolph CS, Cheraskin E: The effect of EDTA chelation therapy plus supportive multivtamin-trace mineral supplementation upon renal function: A study in blood urea nitrogen (BUN). J Holistic Medicine 5(2):163, 1983
Meltzer LE: Chelation Therapy. In Seven MJ and Johnson LA (eds): Metal Binding in Medicine. Philadelphia, JB Lippincott, 1960
Meltzer LE, Palmon FJ, and Kitchell JR: Hypoglycemia induced by disodium ethylenediamine tetra-acetic acid. Lancet 2:637, 1961.
Meltzer LE, Kitchell JR, and Palmon FJ: The long term use, side effects, and toxicity of disodium ethylenediamine tetraacetic acid (EDTA). Am J Med Sci 242:11, 1961
Monaco GP and Green S: Recognizing deception in the promotion of untested and unproven medical treatments. NY State J of Med 2:88, 1993
Myers HL: Topical chelation therapy for varicose pigmentation. Angiology 17:66, 1966.
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Nedergaard OA and Vagne A: Effect of EDTA and other chelating agents on norepinephrine uptake by rabbit aorta in vitro. Proc West Pharmacol Soc 11:87, 1968
Neldner KH, Winklemann RK and Perry HO: Scleroderma. An evaluation of treatment with disodium edetate. Arch Derm 86:305, 1962
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Peng CF, Kane JJ, Murphy ML, Straub KD: Abnormal mitochondrial oxidative phosphorylation of ischemic myocardium reversed by calcium chelating agents. J Mol Cell Cardiol 9:897, 1977
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Rudolph CJ, McDonagh EW and Barber RK: Effect of EDTA chelation and supportive multivitamin/trace mineral supplementation on chronic lung disorders: a study of FVC and FEV1. J Adv Med 2(4): 553,1989
Rudolph CJ, Samuels RT and McDonagh EW: Visual field evidence of macular degeneration reversal using a combination of EDTA and multiple vitamin and trace mineral therapy. J Adv Med 7:203, 1994
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Casdorph HR: EDTA chelation therapy II, efficacy in brain disorders. J Holistic Medicine 3(2):101, 1981.
Casdorph HR, Farr CH: EDTA chelation therapy Ill: Treatment of peripheral arterial occlusion, an alternative to amputation. J Holistic Medicine 3(1):3, 1983.
Chappell LT and Stahl JP: The correlation between EDTA chelation therapy and improvement in cardiovascular function: a meta-analysis. J Adv Med 6(3):139, 1993.
Chappell LT, Stahl JP and Evans R: EDTA chelation treatment for vascular disease: a meta-analysis using unpublished data. J Adv Med 7(3):131, 1994.
Cappell LT, Janson M, Whitaker J: A challenge to cardiovascular surgeons. J Adv Med 9(3): 153, 199
Chappell LT and Margolis S: Point-Counterpoint on EDTA chelation therapy. Alternative Therapies 1(2):53, 1994
Chappell LT: EDTA chelation therapy should be more commonly used in the treatment of vascular disease. Alternative Therapies Health Med 1:53, 1995.
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Clarke NE, Clarke CN, and Mosher RE: Treatment of angina pectoris with disodium ethylene diamine tetra-acetic acid. Am J of Med Sci 232:654, 1956.
Clarke NE Sr: Atherosclerosis, occlusive vascular disease and EDTA. Am J Cardiol 6(2):233, 1960.
Clarke NE, Clarke CN, Mosher RE: The "in vivo" dissolution of metastatic calcium: An approach to atherosclerosis. Am J Med Sci 229:142,1955.
Cranton EM and Frackelton JP: The current status of EDTA chelation therapy in the treatment of occlusive arterial disease. Journal of Holistic Medicine 4: 24, 1982.
Cranton EM: The current status of EDTA chelation therapy, editorial. J Holistic Med 7(1):3, 1985.
Craven, PC and Morelli HF: Chelation therapy. West J Med, 122:277, 1975.
Donald GF, Hunter GA, Roman W and Taylor AEJ: Current concepts of cutaneous porphyria and its treatment with particular reference to the use of sodium calcium-edetate. Brit J Derm 82:70, 1970.
EDTA chelation therapy for arteriosclerotic heart disease. Medical Letter 23,1981.
EDTA chelation therapy for atherosclerotic cardiovascular disease. Medical Letter 36:48 l994.
Friedel W, Schulz FH Schroder L: Therapy of atherosclerosis through mucopolysaccarides and EDTA (ethylene diamine tetraacetic acid). (German) Deutsch Gesundh 20:1566, 1965.
Gibson T: Letter to the editor-The benefits of EDTA chelation therapy for atherosclerosis. Med J Australia 143(3):127, 1985.
Godfrey ME: EDTA chelation as a treatment of arteriosclerosis .N Z Med J 93:199, 1990.
Godfrey ME, Frackleton JP and Chappell LT: Chelation therapy for intermittent claudication (Letter). Z Med J 107:495, 1994
Godfrey ME, Agnihotri R and Strauss A: Chelation and arteriosclerosis. N Z Med J 101(838):21, 1988.
Gordon GB, Vance RB: EDTA chelation therapy for atherosclerosis: History and mechanisms of action. Osteopathic Annals 4:38, 1976.
Gould RG: Metals and chelating agents in relation to atherosclerosis. Fed Proc 20 (Suppl 10):252, 1961
Grumbles LA: Radionuclide studies of cerebral and cardiac arteriography before and after chelation therapy. New Horizons in Holistic Health II (Symposium). Chicago, May 27, 1979.
Guldager B, Jelnes R, Jorgenson SJ, et al: EDTA treatment of intermittent claudication - a double-blind placebo-controlled study. J Intern Med 231:261, 1992.
Hancke C and Flytlie K: Benefits of EDTA chelation therapy in arteriosclerosis: a retrospective study of 470 patients. J Adv Med 6(3):161,1993.
Julian JJ: Pass or Bypass? Chelation Extends Life. Hollywood, Wellness Press, 1981.
Kitchell JR and Meltzer LE: The potential uses of EDTA chelation therapy in the treatment of cardiovascular diseases. Prog of Cardiovascular Dis 3:338, 1961.
Kitchell JR, Palmon F, Aytan N, Meltzer LE: The treatment of coronary artery disease with disodium EDTA, a reappraisal. Am J Cardiol 11:501, 1963.
Lamar CP: Chelation therapy of occlusive arteriosclerosis in diabetic patients. Angiology 15:379, 1964.
Lamar CP: Chelation endarterectomy for occlusive atherosclerosis. J Am Geri Soc 14(3):272, 1966.
Lamar CP: Calcium chelation of atherosclerosis, nine years' clinical experience. Read before the Fourteenth Annual Meeting of the American College of Angiology, San Juan, PR, Dec 8, 1968. (Transcript available from ACAM, 23121 Verdugo Dr., Suite 204, Laguna Hills, CA 92653.)
Lamb DJ and Leake DS: The effect of EDTA on the oxidation of low density lipoprotein. Atherosclerosis 197894:35, 1992.
Malinovska V, Zechmeister A, Brucknerova E et al: Ultrahistochemical study of the effect of glucagon and Chelation III on arterial wall structure after experimental calcification. Folia Morphologica 28:20,
Malinovska V, Zechmeister A, Malinovsky L et al: The therapeutic effect of glucagon and chelation III on the arterial wall after experimental lipidosis and calcification. Scripta Medica 1983:56(7):391
Margolis S: Chelation therapy is ineffective for the treatment of peripheral vascular disease. Alternative Therapies Health Med 1:53, 1995.
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